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KMID : 0383419690100040495
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Korean Modern Medical Journal
1969 Volume.10 No. 4 p.495 ~ p.511
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Clinico-Epidemiological Studies of the Bacterial Infections
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張友鉉/Chang, Woo-Hyun
朴熙明/金漢壽/李承薰/Park, Hee-Myong/Kim, Han-Soo/Lee, Seung-Hoon
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Abstract
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The advancement of modern medicine, particularly the application of effective chemotherapeutics and preventive measures, have brought significant changes on the ecological aspect of microbial diseases of man. It was thought worthwhile to study the recent trends and present status of microbial infections in this country. Thus, the relative incidences and their etiological relationships of bacterial species, the pattern of drug sensitivities among the strains, and also the cases diagnosed by the serological methods were studied for the patients of SNU Hospital from January 1963 to December 1967.
The results might be summarized as follows;
1. Relationships between bacteria and diseases
(1) The species and their relative incidences of bacteria, isolated from various abscess, were α-hemolytic streptococcus 26.6%, Staphyloccus aureus 22.6%, paracolon bacilli 9.9%, coliform bacilli 8.1%, Klebsiella pneumoniae 7.6%, E. coil 6.9%, β-hemolytic streptococcus 5.9%. Staphylococcus albus 3.8%. Proteus 3.8%. Alkaligenes fecalis 2.1%, Diplococcus pneumoniae 1.8% and Pseudomonas aeruginosa 1.6%.
(2) The species and their relative incidences of bacteria, isolated from the pyelonephritis cases, were E. coli, 39.5%, coliform bacilli 13.5%, Pseudomonas aeruginosa 9.3%, Proteus 7.4%, Staphylococcus albus 4.6%, α-hemolytic streptococcus 4.6%, Staphylococcus aureus 2.8%, Klebsiella pnemoniae 2.8%, and Alkaligenes fecalis 2.8%.
(3) The species and their relative incidences of bacteria, isolated from the osteomyelitis cases, were Staphylococcus aureus 46.5%, β-hemolytic streptococcus 12%, Staphyococcus albus 12%, coliform bacilli 6.9%, α-hemolytic streptococcus 6.9%, paracolon bacilli 5.2% and E. coli 3.5%.
(4) The species and their relative incidences of bacteria, isolated from the surgical infections were Staphylococcus aureus 33%, E. coli 15.1%, coliform bacilli 11.6%, Pseudomonas aeruginosa 10.7%, paracolon bacilli 9.8%, Proteus 7.1%, α-hemolytic streptococcus 3.5%, Klebsiella pneumoniae 2.7%, and Alkaligenes fecalis 0.9%.
(5) The species and their relative incidences of bacteria, isolated from the pneumonia cases, were Diplococcus pneumoniae 14.4%, Klebsiella pneumoniae 9.6%, Staphylococcus aureus 10.3%, β-hemolytic streptococcus 4.8%, paracolon bacilli 4.8%, E. coli 3.4%, coliform bacilli 3.4%, α-hemolytic streptococcus 34.6% and Staphylococcus albus 13.6%.
(6) 44 strains of Salmonella group D were isolated.
(7) 207 cases of Salmonella typhosa infections, 39 cases of Salmonella paratyphi A infer ctions and 20 cases of Salmonella paratyphi B infections were diagnosed by Widal. Reactions.
(8) No significant change in the yearly pattern between the bacterial species isolated and clinical cases was noticed.
2. Drug-sensitivities of the bacterial strains.
(1) Percentage of Staphylococcus aureus strains sensitive to streptomycin, chloramphenicol. Or terramycin appeared to have fluctuated by year. Percentages of the strains sensitive to penicillin, erythromycin albamycin, and kanamycin were 25%, 85%, 99% and 99% respectively, without significant change by year.
(2) Perentage of E. coil strain´s sensitive to streptomycin, erythromycin, chloramphenicol albamycin and kanamycin were 30%, 9% 70%, and 70% respectively, without significant change by year. Percentage of the strains sensitive to terramjcin decreased from 33.3% in 1963 to 11.6% in 1967 to kanamycin increased from 72% in 1963 to 82% in 1967. None of the strains was sensitive to penicillin.
(3) Percentage of proteus strains sensitive to penicillin, terramycin, streptomycin and chloramphenicol were 5%, 3%, 36% and 39%, respectively, without significant change by year. Percentage of the strains sensitive to albamycin decreased from 72.5% in 1963 to 50% in 1967 and to kaiiainycin increased from 72% in 1963 to 82% in 1967. None of the strain was sensitive to erythromycin.
(4) Percentage of Pseudomonas strains sensitive to penicillin, streptomycin chloramphenicol, terramycin, erythromycin, albamycin and kanamycin were wider 20%
(5) Percentage of coliform bacilli strains sensitive to penicillin, streptomycin, chloramn henicol, terramycin, erythromycin and albamycin were 10%, 24%, 28%, 20% and 10% respectively, without significant change by year. Percentage of the strains sensitive to albamycin appeared to have fluctuated by year. The strains sensitive to kanamycin decreased from 80% in 1963 to 56% in 1967.
(6) Pereeentage of paracolon bacilli sensitive to penicillin, streptomycin, chloramphenicol, terrahiycin, erythromycin, kanamycin and albamycin were 3%, 27%, 33%, 20%, 8%, 80% and 65% respectively, without significant change by year.
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